MR images can be used to follow-up cerebral anatomy in mouse lemurs. In this review, we present how mouse lemurs can be followed-up by MRI and how MRI can be used during therapeutic evaluations and other applications in this model. Non invasive medical imaging methods such as magnetic resonance imaging (MRI) can be used to follow-up brain changes in these animals. Indeed several animals develop age-associated cerebral alterations like amyloidosis and other cerebral changes. Mouse lemur ( Microcebus murinus) is a small primate (about 12cm, 100g) described as a useful model of cerebral aging and as a potential model of AD. Complementary models such as non-human primates are phylogenetically close to humans and thus more predictive of drug efficiency in humans. However these models do not mimic all the pathophysiological aspects of human diseases. Rodents and particularly transgenic mice are widely used as models for research on physiopathology of cerebral aging, neurodegenerative diseases and for the evaluation of therapies. It leads in many cases to neurodegenerative diseases such as Alzheimer disease (AD). Cerebral aging is a major public health issue in our societies as the aged population increases dramatically.
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